In a very modern review, we claimed the identification as well as characterization of a fresh atypical opioid receptor with unique detrimental regulatory properties in the direction of opioid peptides.one Our outcomes confirmed that ACKR3/CXCR7, hitherto known as an atypical scavenger receptor for chemokines CXCL12 and CXCL11, is usually a wide-spectrum scavenger for opioid peptides in the enkephalin, dynorphin, and nociceptin family members, regulating their availability for classical opioid receptors.

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[four] Molecular and pharmacological aspects of piperine as a potential molecule for condition avoidance and management: proof from scientific trials